Edifix inserts the correct punctuation according to the editorial style you selected, even if parts of your reference are missing. Therefore, when information such as an article title or publication year isn't included in your reference, the punctuation surrounding those missing pieces might look out of place. This is less likely to happen if PubMed and/or Crossref Correction and Linking is enabled, since Edifix will then usually find the missing information and insert it into the reference for you.